Psoriasis is a chronic inflammatory skin disorder that appears in the form of well-demarcated, scaly plaques. Psoriasis is common and affects approximately 2-3% of the white population. Higher rates of cardiovascular morbidity and mortality have been reported in psoriasis patients because of chronic systemic inflammation. Furthermore, metabolic syndrome, smoking, and obesity are known to be more prevalent in psoriasis patients. Dose-response relationships between the higher prevalence of metabolic syndrome components and more severe psoriasis were established.
In addition to inflammation, psoriasis is also considered to originate from an unbalanced immune system with resident cells of the skin. Cadmium is a ubiquitous environmental contaminant and is toxic even at low levels. Chronic exposure to cadmium involves a variety of pathological conditions and constitutes a serious environmental health problem. The usual sources of exposure in the general population are tobacco smoke and diet. Contaminated air and dust can also be important sources in communities near industrial sites and main-road sites.
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Cadmium can increase the risks of multiple-organ disease and metabolic syndrome. Cadmium also causes the elevation of inflammation markers and influences the immune system. The relationship between cadmium and psoriasis, an inflammatory skin disorder, is poorly understood. Accordingly, we hypothesized that cadmium would be positively associated with the severity of psoriasis.
Three things have to be present in the liver for eczema and psoriasis to occur:
1. There has to be a toxic heavy metal inside the liver.
2. There has to be a pathogen-specifically a virus.
3. The liver has to have a certain combination of the right heavy metals and pathogens in order to cause eczema or psoriasis.
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